Brand name: Ferriprox
Generic name: Deferiprone
Used for: Treating iron overload in patients with thalassemia syndromes
Availability: Brand Ferriprox (Chiesi Ltd and Apotex)
How Deferiprone Works
Deferiprone is the active ingredient in Ferriprox; it is a drug used to treat iron overload, specifically in individuals with high iron levels due to frequent blood transfusions. It works by binding excess iron in the bloodstream and tissues to form a chelate, which is then excreted in the urine. It lowers the level of toxic iron and prevents damage to vital organs, such as the heart and liver. Deferiprone has proven effective when used consistently as prescribed by a healthcare professional.
Deferiprone: Possible side effects
Contact your doctor or pharmacist if you experience severe, bothersome side effects. Most of the side effects are manageable and may go away on their own.
• Nausea or vomiting
• Stomach pain
• Joint pain
• Reddish-brown urine discoloration (harmless sign of iron excretion)
• Changes in appetite
Deferiprone Guidelines
Do not take Ferriprox if you are allergic to Deferiprone; talk to your doctor about the risks and benefits before you begin treatment. This medication is associated with agranulocytosis (a decrease in white blood cell count), so patients must be closely monitored with regular blood tests. This medication should not be taken by pregnant women or women who are breastfeeding, as it may cause fetal harm. Your urine may turn reddish-brown. This is a sign that the medication is working and the iron is being successfully excreted from your body.
Avoid consuming alcohol while taking this medication, as it may increase the rate at which the drug is released into your system. The following may interact with Deferiprone, so make sure to tell your doctor about any prescription and over-the-counter medications you are taking:
• Antacids or supplements containing minerals (e.g., iron, aluminum, or zinc) can interfere with the drug's binding to its target.
• Immune-suppressing drugs: Which may increase the risk of serious blood cell count issues.
• Vitamin C: May increase the risk of heart toxicity when taken concurrently with chelators.
The generic alternative is not manufactured by the company that makes the brand product.
All prices are in US dollars.
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