Kombiglyze XR contains a combination of metformin and saxagliptin. Metformin and saxagliptin are oral diabetes medicines that help control blood sugar levels. Kombiglyze XR is the first and only once-a-day metformin extended-release (XR) plus dipeptidyl peptidase-4 (DPP-4) inhibitor combination tablet offering strong glycemic control across glycosylated hemoglobin levels (HbA1c), fasting plasma glucose (FPG) and post-prandial glucose (PPG).
The most common side effects of KOMBIGLYZE XR include upper respiratory tract infection, stuffy or runny nose and sore throat, urinary tract infection, headache, diarrhea, and nausea and vomiting. Do not take Kombiglyze XR if you have kidney problems, are allergic to metformin hydrochloride or any of the ingredients in Kombiglyze XR, or have a condition called metabolic acidosis or diabetic ketoacidosis (increased ketones in your blood or urine). Do not take Kombiglyze XR if you are going to get an injection of dye or contrast agents for an x-ray procedure or will have surgery and not be able to eat or drink much. In these situations, Kombiglyze XR will need to be stopped for a short time. Talk to your healthcare provider about when you should stop and restart Kombiglyze XR.
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