Brand name: Vtama (Nduvra in Canada)
Generic name: Tapinarof
Used for: Topical treatment of plaque psoriasis and atopic dermatitis
Availability: Brand Vtama (Organon)
How Tapinarof Works
Tapinarof is the active ingredient in Vtama; it is a steroid-free drug used to treat inflammatory skin conditions like plaque psoriasis and atopic dermatitis. It works by targeting and activating the aryl hydrocarbon receptor (AhR), which helps regulate immune responses and restores the natural skin barrier function. Unlike steroids, which broadly suppress the immune system, Vtama increases levels of skin barrier proteins and reduces the production of inflammatory cytokines. Tapinarof is prescribed to individuals with mild, moderate, or severe cases of these conditions. It has proven effective when applied as a thin layer to affected areas once daily.
Tapinarof: Possible side effects
Contact your doctor or pharmacist if you experience severe, bothersome side effects. Most side effects are manageable and may go away on their own.
• Abdominal pain
• Contact dermatitis or skin rash.
• Folliculitis (redness or bumps around hair follicles)
• Headache
• Influenza or flu-like symptoms
• Nasopharyngitis (stuffy nose or sore throat)
• Pruritus (itching)
• Vomiting
Tapinarof Guidelines
Do not use Vtama if you are allergic to tapinarof; talk to your doctor about the risks and benefits before you begin treatment. Unlike many other psoriasis treatments, this medication has no label restrictions on the duration of use or the percentage of body surface area treated. Individuals should wash their hands after application unless treating their hands. This medication should be used during pregnancy or breastfeeding only if recommended by a healthcare provider, as its effects in these populations are not fully known. When using on children, ensure the cream is applied only to the affected areas and that the child does not rub the cream into their eyes or mouth. Do not shave or use harsh physical exfoliants immediately before application, as this can increase the risk of red bumps.
According to official labeling, there are no known drug-drug interactions for Vtama cream. However, you should still tell your doctor about:
• Any current prescription and over-the-counter medications
• History of severe allergic reactions to topical products
• Other topical medications are applied to the same area.
There is no generic for this product.
All prices are in US dollars.
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